Quiz - Enols, Enolates, Aldol Condensation | Enols, Enolates and Aldol Condensation - Part 1
Organic Chemistry 2 - Quiz - Enols, Enolates, Aldol Condensation
Which of the following reagents can deprotonate a hydrogen on a carbon in the α position of a carbonyl?
H on an α-carbon of a carbonyl has a pKa ~ 16-18 (aldehyde) and ~ 19-21 (ketone). Et3N (pKa = 10.8), NaOH (pKa = 15.7) and CH3COO- (pKa = 4.76) are not strong enough to deprotonate this species unlike LDA (pKa = 36)
What is the product of an aldol condensation?
What is the reactivity of an α,β-unsaturated aldehyde or ketone?
Reactivity of an α,β-unsaturated aldehyde or ketone:
- typical reactions of alkenes and carbonyls
- 1,4-additions (and sometimes 1,2-additions)
What is the product of the reaction between water and pent-3-en-2-one?
Which of the following statements about keto-enol equilibrium is correct?
Carbonyls are in equilibrium with their enol forms (10 kcal.mol-1 less stable). This equilibrium can be catalyzed by a base or by an acid
Which of the following molecules is the most acidic?
β-diketone (pKa = 9) < Aldehyde (pKa ~ 16-18) < Ketone (pKa ~ 19-21) < Ester (pKa ~ 25)