Aldehydes and Ketones – Part 2 | Organic Chemistry 3

The Carbonyls are studied in this chapter: the deoxygenation of carbonyls, the addition of cyanide, the Wittig reaction, the Baeyer-Villiger oxidation. This chapter is a continuation of chapter 7 – Organic Chemistry 2.

Deoxygenation of the Carbonyl Group


1st step: Synthesis of a Hydrazone


2nd step: Wolff-Kishner Reduction



Addition of Hydrogen Cyanide


Wittig Reaction


Preparation of the phosphorus ylides:


Mechanism of Wittig Reaction:

Baeyer-Villiger Oxidation


Mechanism: Oxidation by Peroxycarboxylic Acids


With unsymmetric ketones, the esters can be formed selectively by migration of only one of the substituents. 
Migratory aptitudes in Baeyer-Villiger reaction:
Methyl  <  Primary Alkyl < Phenyl ~ Secondary Alkyl < Tertiary Alkyl