Organic Chemistry 1
Introduction to Organic Chemistry: bonding theory, chemical and physical properties, structure and reactivities, isomerism, stereochemistry. Introduction to substitution, addition, and elimination reactions. Methodology for retrosynthetic analysis.
Organic compounds contain carbon atoms bonded hydrogen and other carbon atoms. Organic chemistry studies the properties and reactions of organic compounds. The structure and bonding in organic molecules are studied in this chapter: the atomic structure and electron configurations, the ionic and covalent bonds (octet rule), the formal charges, the hybridization types, the different molecular structures and resonance forms.
Structure and reactivity in organic chemistry are studied in this chapter: the three classes of reagents (Bronsted acids/bases, Lewis acids/bases, nucleophile/electrophile), the chemical functional groups, the naming of alkanes (an example of naming in organic chemistry), introduction to isomerism.
Reactions of alkanes are studied in this chapter: the important concepts of saturated hydrocarbons (equivalent atoms, primary, secondary, tertiary, quaternary atoms in chemistry, stability of radicals), the two types of reactivity in organic chemistry (heterolytic vs. homolytic), the radical chain reactions, the halogenation of alkanes (mechanism, products and selectivity).
Cycloalkanes are studied in this chapter: introduction to stereoisomerism, ring strain, chair conformations (strain free conformations of cyclohexane), substituted cyclohexanes.
Stereoisomerism concept is studied in this chapter: the chirality of chemical compounds, the absolute configuration of a stereocenter, the types of stereoisomers (enantiomers, diastereomers, meso compound), the optical activity of stereoisomers, the racemic mixture and enantiomeric excess.
Properties and reactivities of Haloalkanes is studied in this chapter: physical properties of haloalkanes, polar reactions, introduction to one of the most important types of reactions in organic chemistry: nucleophilic substitution reactions (SN reactions).
Further reactions of haloalkanes are studied in this chapter: In-depth study of SN reactions, competition between SN1 and SN2, introduction to another important types of reactions: elimination (E reactions), competition between E1 and E2, competition between SN and elimination reactions.
The hydroxy functional group (alcohol) is studied in this chapter: the naming and properties of alcohols, the synthesis of alcohols (SN reaction, reduction of carbonyls, organometallics), the carbon-carbon bonds formation.
The reactivity of alcohols and the chemistry of ethers are studied in this chapter: the typical reactions of alcohols (deprotonation, substitution, elimination, oxidation), the rearrangements in organic chemistry, the ethers synthesis, the reactivity of epoxides.
The strategies in retrosynthesis are studied in this chapter: the protection/deprotection of chemical function groups, the retrosynthetic analysis, the summary of the chemical transformations seen so far.
Midterm 1 includes 7 questions and it covers Chapters 1, 2 and 3 of Organic Chemistry 1. At the end of the test you can see the answers and determine whether you have solved the questions. You have 1 hour to resolve Midterm 1.
Midterm 2 includes 8 questions and it covers chapters 1 to 6 of Organic Chemistry 1 (mainly chapters 4, 5 and 6). At the end of the test you can see the answers and determine whether you have solved the questions. You have 1 hour to resolve Midterm 2.
Final Exam includes 14 questions and it covers all chapters of Organic Chemistry 1. At the end of the test you can see the answers and determine whether you have solved the questions. You have 3 hours to resolve Final Exam.