Quiz | Synthesis and Retrosynthesis Strategies

1

What is the good strategy in retrosynthetic analysis?

Work backwards (from the final product to immediate precursors …)

Count the number of carbons and determine the disconnections needed)

Check the available compounds and think about the immediate possible intermediate

All of the above

2

Which of the following conditions results in the formation of a C-C bond?

alkyl halide + EtONa

alcohol + CH3SOCl2

organometallics + alcohol

organometallics + carbonyls

3

How can you protect an alcohol?

(CH3)3COH in acid condition

(CH3)3COH in basic condition

Li to transform it into organometallic

PBr3 to transform it into alkyl halide

4

What kind of compounds should CH3MgBr react with to form propanol?

aldehyde

ketone

epoxide

alcohol

5

What is the first step of the formation of the butanone starting from methyl lithium and propanol?

oxidation of the propanol with Na2Cr2O7

oxidation of the propanol with PCC

protection of the alcohol

reduction of the alcohol with LiAlH4

6

What is the first step of the formation of the 1-methylcyclohexane-1,3-diol starting from methyllithium and 3-hydroxycyclohexanone?

oxidation of the alcohol with Na2Cr2O7

oxidation of the alcohol with PCC

protection of the alcohol

reduction of the ketone with LiAlH4