SN1 vs. SN2 - 4 | Alkyl Halides - Nucleophilic Substitutions
Organic Chemistry 1 - SN1 vs. SN2 - 4
Which solvents favor SN1 reactions and which favor SN2 reactions?
CH3CN, acetone (CH3)2C=O, CH3COOH, CH3CH2OH, Et2O, DMSO (CH3)2S=O, H2O
Polar protic solvents favor the SN1 mechanism while polar aprotic solvents favor the SN2 mechanism.
Polar protic solvents: CH3COOH, CH3CH2OH, H2O ⇒ SN1 reactions
Polar aprotic solvents: CH3CN, acetone, Et2O, DMSO ⇒ SN2 reactions