Quiz - Alkyl Halides - SN Reactions 1 | Alkyl Halides - Nucleophilic Substitutions
Organic Chemistry 1 - Quiz - Alkyl Halides - SN Reactions 1
Which of the following bonds has the greatest bond dipole moment?
Fluorine is the most electronegative halogen atom. The difference in electronegativity between fluorine and hydrogen is the greatest ⇒ H-F has the greatest bond dipole moment
Which statement is incorrect about the reaction of 1-bromobutane and hydroxide ion?
1-bromobutane is an haloalkane with a good leaving halogen atom (Br-)
Hydroxide ion HO- is a good nucleophile
The reaction between 1-bromobutane and HO- is a SN2 which do not proceed via an intermediate ⇒ the reaction proceeds via only one step
Which of the following group is not a good leaving group?
HO- is not a good leaving group but a good nucleophile
Which of the following is least likely to undergo an SN2 reaction?
Steric effects are particularly important in SN2 reactions: the greater the steric hindrance around the reaction center, the less reactive the compound
Why do SN2 reactions proceed with inversion of configuration at the chiral carbon?
In SN2 reactions, the nucleophile attacks from the opposite side of the leaving group, leading to inversion of configuration. This backside attack is required to achieve the necessary steric alignment for the bimolecular reaction mechanism.
Which statement is incorrect?
During an SN2 reaction, the nucleophile attacks the electrophile center on the opposite side of the good leaving group. The other substituents flip from one side to the other: this is the inversion of configuration. However, inversion of configuration does not mean inversion of the absolute configuration of the chiral center
Which of the following nucleophiles is the best?
NC- is electron-rich and the negative charge is on the carbon atom. Carbon is less electronegative than oxygen and chlorine ⇒ NC- is a stronger nucleophile than HO- and Cl-
H2O is not electron-rich ⇒ it is not a good nucleophile
Which of the following solvents is commonly used in polar reactions?
Water is a polar solvent commonly used in polar reactions due to its ability to dissolve polar and ionic compounds.
What does the term "alkyl halide" refer to in chemical nomenclature?
Alkyl halides are hydrocarbons with one or more hydrogen atoms replaced by halogen atoms.
In the IUPAC nomenclature for alkyl halides, how are halogen substituents indicated?
In IUPAC nomenclature, halogen substituents in alkyl halides are indicated as a prefix specifying the type of halogen (e.g., chloro, bromo).