Quiz - Carboxylic Acid Derivatives | Carboxylic Acid Derivatives - Part 1

Organic Chemistry 2 - Quiz - Carboxylic Acid Derivatives


What is the order of reactivity of the carboxylic acid derivatives from the least reactive to the most reactive?


Which carboxylic acid derivative has the most acidic proton on the α-carbon?

The pKa of hydrogens on the α-carbon depends on the electronegativity of the group attached to the C=O bond ⇒ the lower the electronegativity, the higher the pKa. Acyl halide: pKa ~ 16; Carboxylic anhydride: pKa ~ 20; Ester: pKa ~ 25; Amide: pKa ~ 30


What is the typical chemical reaction of carboxylic acid derivatives?


Which of the following reagents converts an ester to an aldehyde?


What are the starting reagents of a transesterification?

Mechanism of transesterification:


Which of the following reagents converts an amide to an amine?