Quiz - Carboxylic Acid Derivatives - 3 | Carboxylic Acid Derivatives - Acid Halides, Esters
Organic Chemistry 2 - Quiz - Carboxylic Acid Derivatives - 3
What is the order of reactivity of the carboxylic acid derivatives from the least reactive to the most reactive?
Which carboxylic acid derivative has the most acidic proton on the α-carbon?
The pKa of hydrogens on the α-carbon depends on the electronegativity of the group attached to the C=O bond ⇒ the lower the electronegativity, the higher the pKa. Acyl halide: pKa ~ 16; Carboxylic anhydride: pKa ~ 20; Ester: pKa ~ 25; Amide: pKa ~ 30
What is the typical chemical reaction of carboxylic acid derivatives?
Which of the following reagents converts an ester to an aldehyde?
What are the starting reagents of a transesterification?
Mechanism of transesterification:
Which of the following reagents converts an amide to an amine?
