Quiz - Carbonyl Condensation Reactions - 2 | Carbonyl Condensation Reactions

Organic Chemistry 3 - Quiz - Carbonyl Condensation Reactions - 2


Which of the following best describes the mechanism of the aldol condensation?

The aldol condensation involves the nucleophilic addition of an enolate ion to a carbonyl group of an aldehyde or ketone, followed by dehydration to form an α,β-unsaturated carbonyl compound.


What is the main difference between an Aldol Reaction and a Crossed Aldol Reaction?

A Crossed Aldol Reaction differs from a regular Aldol Reaction by involving two different aldehyde or ketone reactants. It is essential to select conditions or reactants to avoid polysubstitution and to achieve the desired selectivity.


Intramolecular Aldol Reactions are typically used to synthesize which type of compounds?

Intramolecular Aldol Reactions enable the formation of five- and six-membered carbocycles by the reaction of an enolate with a carbonyl group within the same molecule.


Which compound is commonly used as the base for Claisen Condensations?

The ethoxide ion is a commonly used base in the Claisen Condensation, as it is the conjugate base of ethanol that is also used as the solvent, enabling facile self-protonation to regenerate itself, thus driving the reaction.


The Dieckmann Cyclization is a specific type of which reaction category?

The Dieckmann Cyclization is a specific type of Claisen Condensation, where intramolecular reaction of two ester groups within the same molecule forms a β-keto ester and a cyclic compound.


In a Michael Addition, the nucleophile typically attacks which carbon of the α,β-unsaturated carbonyl compound?

In a Michael Addition, the nucleophile attacks the β carbon of an α,β-unsaturated carbonyl compound, which is electrophilic due to conjugation with the carbonyl group.


Stork Enamine Synthesis involves the formation of an enamine intermediate that then reacts with an electrophile. What is the source of the enamine?

Stork Enamine Synthesis involves the reaction of a ketone with a secondary amine to form an enamine, which can then act as a nucleophile and react with electrophiles, such as alkyl halides.


Which reaction involves the treatment of an enamine with an alkyl halide to form an alkylated product?

Enamine Alkylation involves the reaction of an enamine with an alkyl halide, allowing for the alkylation at the α carbon of the original carbonyl compound.


Robinson Annulation combines which two reaction types to construct a bicyclic ring system?

Robinson Annulation is a tandem reaction sequence combining a Michael Addition with an Aldol Condensation to construct a bicyclic system, with the Michael Addition providing the carbon nucleophile that initiates the process.


What is a notable advantage of alkylation of enamines compared to alkylation of carbonyl compounds?


Alkylation of enamines typically avoids polyalkylation issues commonly encountered in alkylation of enolates.