Quiz - Aldehydes and Ketones - 3 | Aldehydes and Ketones - Part 2
Organic Chemistry 2 - Quiz - Aldehydes and Ketones - 3
What is the major product when a secondary amine reacts with a ketone?
The major product is an enamine. The difference between the formation of imines and enamines is that, with a secondary amine, the iminium ion intermediate does not have a proton on the nitrogen ⇒ a proton must be removed from an adjacent C-H bond, forming a C=C.
Which compound is not formed during the Wolff-Kishner reduction of an aldehyde?
A carboxylic acid is not formed during the Wolff-Kishner reduction. This reaction transforms a carbonyl group into an alkane by converting the carbonyl to a hydrazone which is then decomposed to an alkane and nitrogen gas.
Which conditions can be used for the addition of a cyanide ion to an aldehyde?
KCN in the presence of an acid such as HCl is essential for the addition of a cyanide ion to an aldehyde, resulting in the formation of a cyanohydrin.
In the Wittig reaction, what type of compound reacts with an aldehyde to form an alkene?
In the Wittig reaction, a phosphonium ylide reacts with an aldehyde to form an alkene. The ylide is the active species generated from a phosphonium salt by deprotonation.
During the Baeyer-Villiger oxidation, what functional group is introduced next to the carbonyl group of a ketone?
An ester group is introduced next to the carbonyl group of a ketone during the Baeyer-Villiger oxidation. This reaction involves the insertion of an oxygen atom from a peracid into the carbon-carbon bond of the carbonyl, resulting in an ester.
Which reagent would you use to add a carbanion to an aldehyde?
Methyl lithium (MeLi) would be used to add a carbanion to an aldehyde. MeLi acts as a strong base and a nucleophile, allowing for the formation of an alcohol after the addition of the carbanionic carbon to the carbonyl group.
What is the result of the addition of hydrides to an aldehyde?
The result of the addition of hydrides to an aldehyde is a primary alcohol. Hydride reagents like NaBH4 and LiAlH4 are commonly used for the reduction of aldehydes.
Which type of reaction occurs when an α,β-unsaturated aldehyde reacts with a nucleophile in a Michael addition?
A nucleophilic addition to the β-carbon occurs when an α,β-unsaturated aldehyde undergoes a Michael addition. The nucleophile adds to the β-carbon atoms due to the conjugated double bond system.
Which organometallic reagent always results in an 1,4-addition?
Organolithium reagents (RLi): 1,2-addition
Gilman reagents (R2CuLi): 1,4-addition
Grignard reagents (RMgBr): 1,2 or 1,4-addition depending on reagent and substrate structure