Quiz - Carboxylic Acid Derivatives | Carboxylic Acid Derivatives – Part 2
Which proton of an amide is the most acidic?
The proton on the carbonyl
The proton on the nitrogen atom
The proton on the carbon atom in α position
It depends on the conditions (temperature and concentration)
What is the first step in the Hofmann rearrangement?
Nucleophilic attack of the hydroxide ion on the carbonyl
Acid-activation of the carbonyl
Halogenation of the amide
Deprotonation of the amide and formation of an amidate
Step 1 in the Hofmann rearrangement: amidate formation
What are the products of the Hofmann rearrangement?
An amine and CO2
An amide and CO2
An amine and NH3
A carboxylic acid and NH3
Hofmann Rearrangement:
Which of the following statements is incorrect about alkanenitriles?
The substituent -CN is called cyano
CN is linear and carbon and nitrogen atoms are sp-hybridized
Nitriles take precedence over carboxylic acids in the nomenclature
A cycloalkane with a nitrile substituent is called cycloalkanecarbonitrile
Nitriles take precedence over aldehydes, ketones, amines, alkenes, alkynes but not over carboxylic acids
Which of the following reagents converts a nitrile to an aldehyde?
LiAlH4
R2AlH
H2, PtO2
RMgBr
Reduction of nitriles resulting in the formation of aldehydes:
What is the product of the hydrolysis of nitriles?
An alcohol
An aldehyde
A ketone
A carboxylic acid
Hydrolysis of nitriles:
